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Article

SARS coronavirus 7a protein blocks cell cycle progression at G0/G1 phase via the cyclin D3/pRb pathway.

Virology - 1 Mar 2006

Yuan Xiaoling, Wu Jie, Shan Yajun, Yao Zhenyu, Dong Bo, Chen Bo, Zhao Zhenhu, Wang Shenqi, Chen Jiapei, Cong Yuwen

Abstract excerpt

The genome of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) contains four structural genes that are homologous to genes found in other coronaviruses, and also contains six subgroup-specific open reading frames (ORFs). Expression of one of these subgroup-specific genes, ORF7a, resulted in apoptosis via a caspase-dependent pathway. Here, we observed that transient expression of ORF7a protein...

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Identifiers

PMID: 16303160
DOI: 10.1016/j.virol.2005.10.015
PMCID: PMC7111786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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