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Article

G1 phase cell cycle arrest induced by SARS-CoV 3a protein via the cyclin D3/pRb pathway.

American journal of respiratory cell and molecular biology - 1 Jul 2007

Yuan Xiaoling, Yao Zhenyu, Wu Jie, Zhou Yusen, Shan Yajun, Dong Bo, Zhao Zhenhu, Hua Ping, Chen Jiapei, Cong Yuwen

Abstract excerpt

SARS-CoV 3a is a structural protein, mainly localizing to Golgi apparatus and co-localizing with SARS-CoV M in co-transfected cells. Here we observed that transient expression of 3a inhibited cell growth and prevented 5-bromodeoxyuridine incorporation, suggesting that 3a deregulated cell cycle progression. Cell cycle analysis demonstrated that 3a expression was associated with blockage of cell cycle progression...

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PMID: 17413032
DOI: 10.1165/rcmb.2005-0345RC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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