All paired up with no place to go: pairing, synapsis, and DSB formation in a balancer heterozygote.

doi:10.1371/journal.pgen.0010067

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Article

All paired up with no place to go: pairing, synapsis, and DSB formation in a balancer heterozygote.

PLoS genetics - 1 Nov 2005

Gong Wei J, McKim Kim S, Hawley R Scott

Abstract excerpt

The multiply inverted X chromosome balancer FM7 strongly suppresses, or eliminates, the occurrence of crossing over when heterozygous with a normal sequence homolog. We have utilized the LacI-GFP: lacO system to visualize the effects of FM7 on meiotic pairing, synapsis, and double-strand break formation in Drosophila oocytes. Surprisingly, the analysis of meiotic pairing and synapsis for three lacO reporter...

Topics

Animals
Chromosome Pairing
Crossing Over, Genetic
Drosophila
Genes, Reporter
Genetic Techniques
Heterozygote
Meiosis
Models, Genetic
Mutation
Oocytes
Rad51 Recombinase
X Chromosome

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Identifiers

PMID: 16299588
DOI: 10.1371/journal.pgen.0010067
PMCID: PMC1285065

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