Article
Androgen mediation of thrombocytosis in epithelial ovarian cancer biology.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2005
Li Andrew John, Karlan Beth Young
Abstract excerpt
PURPOSE: Preoperative thrombocytosis (platelet count > 400 x 10(9)/L) at initial exploration for epithelial ovarian carcinoma is associated with decreased surgical cytoreducibility and poor survival. Platelets express androgen receptor (AR), which contains a polymorphic CAG trinucleotide repeat sequence of which the length inversely correlates with AR transactivation function. We hypothesized that...
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