Article
Evidence that a salt bridge in the light chain contributes to the physical stability difference between heavy and light human ferritins.
The Journal of biological chemistry - 15 Jul 1992
Santambrogio P, Levi S, Arosio P, Palagi L, Vecchio G, Lawson D M, Yewdall S J, Artymiuk P J, Harrison P M, Jappelli R
Abstract excerpt
Human ferritin, a multimeric iron storage protein, is composed by various proportions of two subunit types: the H- and L-chains. The biological functions of these two genic products have not been clarified, although differences in reactivity with iron have been shown. Starting from the hypothesis...
Topics
- Amino Acid Sequence
- Binding Sites
- Circular Dichroism
- Computer Graphics
- Computer Simulation
- Escherichia coli
- Ferritins
- Genetic Variation
- Humans
- Kinetics
- Macromolecular Substances