Article
Expression of bestrophin-1, the product of the VMD2 gene, modulates voltage-dependent Ca2+ channels in retinal pigment epithelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2006
Rosenthal Rita, Bakall Benjamin, Kinnick Tyson, Peachey Neal, Wimmers Sönke, Wadelius Claes, Marmorstein Alan, Strauss Olaf
Abstract excerpt
Mutations in the VMD2 gene cause Best's disease, an inherited form of macular degeneration. The reduction in the light-peak amplitude in the patient's electro-oculogram suggests that bestrophin-1 influences the membrane conductance of the retinal pigment epithelium (RPE). Systemic application of the L-type Ca2+ channel blocker nimodipine reduced the light-peak amplitude in the rat electroretinogram but not a- and...
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