Article
Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas.
Mutation research - 22 Feb 2006
Silva Javier, Silva José M A, Barradas Marta, García José M, Domínguez Gemma, García Vanesa, Peña Cristina, Gallego Isabel, Espinosa Ruth, Serrano Manuel, Bonilla Félix
Abstract excerpt
Frequent chromosome 3 losses have been described in several tumors types, which strongly suggest the presence of one or several tumor suppressor genes. Recently, a novel candidate tumor suppressor gene termed Ris-1 (for Ras-induced senescence 1) has been identified at chromosomal position 3p21.3. Ris-1 has been proposed to participate in anti-tumor responses that resemble cellular senescence and that are elicited...
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