Article
Spread of human cancer cells occurs with probabilities indicative of a nongenetic mechanism.
British journal of cancer - 28 Nov 2005
Michaelson J S, Cheongsiatmoy J A, Dewey F, Silverstein M J, Sgroi D, Smith B, Tanabe K K
Abstract excerpt
There has been much uncertainty as to whether metastasis requires mutation at the time of spread. Here, we use clinical data to calculate the probability of the spread of melanoma and breast cancer cells. These calculations reveal that the probability of the spread of cancer cells is relatively high for small tumours (approximately 1 event of spread for every 500 cells for melanomas of 0.1 mm) and declines as...
Topics
- Breast Neoplasms
- Female
- Humans
- Lymphatic Metastasis
- Male
- Melanoma
- Models, Statistical
- Mutation
- Neoplasm Metastasis
- Neoplastic Cells, Circulating
- Risk Assessment
- Skin Neoplasms