Article
Common polymorphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men.
Molecular genetics and metabolism - 1 Feb 2006
Mousavinasab Firoozeh, Tähtinen Tuula, Jokelainen Jari, Koskela Pentti, Vanhala Mauno, Oikarinen Jorma, Keinänen-Kiukaanniemi Sirkka, Laakso Markku
Abstract excerpt
Epidemiologic studies have shown that serum level of adiponectin, a circulating protein secreted by adipocytes, predicts the risk of type 2 diabetes and cardiovascular events. Two single-nucleotide polymorphisms (SNPs) at the adiponectin locus (T45G or G276T) of the adiponectin gene (APM1) have been associated with insulin resistance, low serum adiponectin levels, and diabetes. In the present study, the...
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