Article
Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus.
Arthritis and rheumatism - 1 Nov 2005
Popovic Karin, Ek Monica, Espinosa Alexander, Padyukov Leonid, Harris Helena Erlandsson, Wahren-Herlenius Marie, Nyberg Filippa
Abstract excerpt
OBJECTIVE: To investigate the role of the novel cytokine high mobility group box chromosomal protein 1 (HMGB-1) in the pathogenesis of cutaneous lupus erythematosus (CLE). METHODS: Punch biopsy specimens of lesional and unaffected skin from 10 patients with CLE and 3 healthy control subjects were investigated. Immunohistochemical staining for HMGB-1, tumor necrosis factor alpha (TNFalpha), and interleukin-1beta...
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