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Article

Maternal CD46H2 and IL1B-5111 homozygosity in T helper 1-type immunity to trophoblast antigens in recurrent pregnancy loss.

Human reproduction (Oxford, England) - 1 Mar 2006

Wang Zhigang C, Hill Joseph A, Yunis Edmond J, Xiao Ling, Anderson Deborah J

Abstract excerpt

BACKGROUND: Women with recurrent pregnancy loss (RPL) and T-helper (Th)1-type immunity to trophoblast antigens have an increased frequency of the IL1B-511*1 promoter variant. Since CD46 gene products also regulate maternal immune responses including Th1 immunity, we investigated whether CD46 gene polymorphisms are also associated with RPL in women with and without Th1 immunity to trophoblast, and the possibility...

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Identifiers

PMID: 16253969
DOI: 10.1093/humrep/dei366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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