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Article

Fgl2 prothrombinase expression in mouse trophoblast and decidua triggers abortion but may be countered by OX-2

1 Feb 2001

Abstract excerpt

Spontaneous abortion of normal karyotype embryos in mice and in humans is associated with an increase in uterine T helper (Th) 1 type proinflammatory cytokines, tumour necrosis factor (TNF)-alpha, interferon-gamma and interleukin (IL)-1, and a deficiency of Th2/3 type cytokines, IL-4, IL-10, and transforming growth factor (TGF)-beta2. In mice, Th1 cytokines up-regulate a novel prothrombinase, fgl2, which via...

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PMID: 11160845
DOI: 10.1093/molehr/7.2.185

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