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Article

Functional characterization of the SOFA delta ribozyme.

RNA (New York, N.Y.) - 1 Dec 2005

Bergeron Lucien Junior, Reymond Cédric, Perreault Jean-Pierre

Abstract excerpt

Molecular engineering has led to the development of a novel target-dependent riboswitch that increases deltaribozyme fidelity. This delta ribozyme possesses a specific on/off adapter (SOFA) that switches the cleavage activity from off (a "safety lock") to on solely in the presence of the desired RNA substrate. In this report, we investigate the influence of both the structure and the sequence of each domain of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16251383
DOI: 10.1261/rna.2112705
PMCID: PMC1370874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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