Article
[HLA polymorphism in the susceptibility or resistance to dilated cardiomyopathy].
Giornale italiano di cardiologia - 1 Jan 1992
Martinetti M, Salvaneschi L, Graziano G, Arbustini E, Diegoli M, Dondi E, Pizzochero C, Gavazzi A
Abstract excerpt
Much of the surrounding studies on the association between HLA and diseases reflects a new insight into the key role of HLA molecules in the generation and regulation of the immune response. HLA molecules, on the surface of antigen presenting cells, bind foreign peptides. This HLA-antigen complex is then recognized by T lymphocytes and triggers the alloresponse against the peptide. Since many diseases associated...
Topics
- Cardiomyopathy, Dilated
- Chromosome Mapping
- Disease Susceptibility
- Genes, MHC Class I
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA Antigens
- Humans
- Polymorphism, Genetic