Possible involvement of the HLA-DQB1 gene in susceptibility and resistance to human dilated cardiomyopathy.

doi:10.1016/0002-8703(95)90395-x

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Article

Possible involvement of the HLA-DQB1 gene in susceptibility and resistance to human dilated cardiomyopathy.

American heart journal - 1 Jun 1995

Limas C J, Limas C, Goldenberg I F, Blair R

Abstract excerpt

There is evidence that autoimmunity plays a role in the pathogenesis of dilated cardiomyopathy and that susceptibility to the disease is related to products of human leukocyte antigens (HLA) class II genes. We compared the distribution of HLA-DQA1 and -DQB1 alleles and haplotypes in 44 normal controls and 34 patients with idiopathic dilated cardiomyopathy patients. The distribution of two DQA1-DQB1 haplotypes...

Topics

Adult
Alleles
Autoantibodies
Base Sequence
Cardiomyopathy, Dilated
Disease Susceptibility
Female
Genes, MHC Class II
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Histidine

Homozygote

Humans

Leucine

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 7754945
DOI: 10.1016/0002-8703(95)90395-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7754945-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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