Article
Genetic analysis of dilated cardiomyopathy--HLA and immunoglobulin genes may confer susceptibility.
Japanese circulation journal - 1 Oct 1992
Nishi H, Kimura A, Fukuta S, Kusukawa R, Kawamura K, Nimura Y, Nagano M, Yasuda H, Kawai C, Sugimoto T
Abstract excerpt
To identify genetic factors in the immune system which control the susceptibility to dilated cardiomyopathy (DCM), HLA class II DNA typing was performed in 61 Japanese patients, using PCR/SSO probe analyses. The frequencies of HLA-DQB1*0503 (15% vs 5%; RR = 3.06, chi 2 = 7.19) and DQB1*0604 (21% vs 10%; RR = 2.41, chi 2 = 6.20) were significantly increased and that of HLA-DQB1*0502 (RR = 1.74) was slightly...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Base Sequence
- Cardiomyopathy, Dilated
- Disease Susceptibility
- Female
- Genes, Immunoglobulin
- HLA-DQ Antigens
- HLA-DQ beta-Chains