Article
The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.
Science (New York, N.Y.) - 21 Oct 2005
Chang Q, Hoefs S, van der Kemp A W, Topala C N, Bindels R J, Hoenderop J G
Abstract excerpt
Blood calcium concentration is maintained within a narrow range despite large variations in dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has been implicated in this process. We report here that TRPV5 is stimulated by the mammalian hormone klotho. Klotho, a beta-glucuronidase, hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane. This...
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