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Cervical human papillomavirus screening by PCR: advantages of targeting the E6/E7 region

1 Jan 2005

Abstract excerpt

PCR is a promising method for detection of human papillomavirus (HPV), the high-risk forms of which are responsible for cervical cancer. PCR primers that target the L1 or E1 region can be unreliable and may miss more advanced disease, whereas those directed at the E6 or E7 regions, which encode oncogenic products, are preferable because 1) the LI/E1 regions, but never the E6/E7 regions, are lost during...

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PMID: 16232081
DOI: 10.1515/cclm.2005.203

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