Bovine Herpesvirus 4 Induces Apoptosis of Human Carcinoma Cell Lines <i>In vitro</i> and <i>In vivo</i>

Abstract excerpt

The idea of using oncolytic viruses for the treatment of cancers was proposed a century ago. During the last two decades, viruses able to replicate specifically in cancer cells and to induce their lysis were identified and were genetically modified to improve their viro-oncolytic properties. More recently, a new approach consisting of inducing selective apoptosis in cancer cells through viral infection has been...

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