Article
A new insertion in the HIV-1 reverse transcriptase gene inducing major resistance to non-nucleoside reverse transcriptase inhibitors.
AIDS (London, England) - 4 Nov 2005
Amiel Corinne, Desire Nathalie, Schneider Veronique, Delphin Nathalie, Race Ester, Clavel Françoise, Piolot Tristan, Dam Elisabeth, Rozenbaum Willy, Nicolas Jean-Claude
Abstract excerpt
We identified an HIV-1 isolate with a 3 base pairs insertion in the 100-105 region of the reverse transcriptase gene (RT) along with a G190E and a V75A mutation. Virus carrying the insertion alone or in association with G190A was not infectious. The association of G190E and the 100-105 insertion displayed a high level of resistance to non-nucleoside reverse transcriptase inhibitors; the addition of the insertion...
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