Article
Differentiation of circulating endothelial progenitor cells to a cardiomyogenic phenotype depends on E-cadherin.
FEBS letters - 7 Nov 2005
Koyanagi Masamichi, Urbich Carmen, Chavakis Emmanouil, Hoffmann Jörg, Rupp Stefan, Badorff Cornel, Zeiher Andreas M, Starzinski-Powitz Anna, Haendeler Judith, Dimmeler Stefanie
Abstract excerpt
Progenitor cells may contribute to cardiac regeneration. Here, we investigated the role of cadherins and integrins for differentiation of human adult circulating endothelial progenitor cells (EPCs) into cardiomyocytes (CM) in a co-culture system. N- and E-cadherin were expressed in EPCs and were localized at the interface between EPCs and CM. Incubation of a blocking antibody against E-cadherin reduced the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
