Article
Cold-induced expression of the VEGF gene in brown adipose tissue is independent of thermogenic oxygen consumption.
FEBS letters - 24 Oct 2005
Fredriksson J Magnus, Nikami Hideki, Nedergaard Jan
Abstract excerpt
To examine whether cold-induced vascular endothelial growth factor (VEGF) gene expression in brown adipose tissue involved generation of hypoxic oxygen levels by thermogenic processes, we cold-exposed wild-type mice, as well as uncoupling protein-1 (UCP1)-ablated mice in which no thermogenesis in brown adipocytes can be induced. Cold exposure stimulated VEGF expression in both wild-type and UCP1-ablated mice....
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