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Tumours from <i>MSH2</i> mutation carriers show loss of MSH2 expression but many tumours from <i>MLH1</i> mutation carriers exhibit weak positive MLH1 staining

10 Oct 2005

Abstract excerpt

Microsatellite analysis (MSA) in tumour tissue is useful for pre-selection of hereditary non-polyposis colorectal cancer (HNPCC) patients for mutation screening, but is time-consuming and cost-intensive. Immunohistochemistry (IHC) for expression of MLH1 and MSH2 proteins is simple, fast, and indicates the affected gene. IHC has therefore been proposed as an alternative pre-screening method. However, some authors...

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PMID: 16216036
DOI: 10.1002/path.1858

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