Article
Polymorphisms in the gene encoding angiotensin I converting enzyme 2 and diabetic nephropathy.
Diabetologia - 1 Nov 2005
Fröjdö S, Sjölind L, Parkkonen M, Mäkinen V-P, Kilpikari R, Pettersson-Fernholm K, Forsblom C, Fagerudd J, Tikellis C, Cooper M E, Wessman M, Groop P-H
Abstract excerpt
AIMS/HYPOTHESIS: Substantial evidence exists for the involvement of the renin-angiotensin system (RAS) in diabetic nephropathy. Angiotensin I converting enzyme 2 (ACE2), a new component of the RAS, has been implicated in kidney disease, hypertension and cardiac function. Based on this, the aim of the present study was to evaluate whether variations in ACE2 are associated with diabetic nephropathy. MATERIALS AND...
Topics
- Adult
- Angiotensin-Converting Enzyme 2
- Carboxypeptidases
- Case-Control Studies
- Cross-Sectional Studies
- Diabetes Mellitus, Type 1
- Diabetic Nephropathies
- Female
- Finland
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Male