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Article

Combined estrogen receptor alpha and estrogen receptor beta genotypes influence the age of menarche.

Human reproduction (Oxford, England) - 1 Feb 2006

Stavrou I, Zois C, Chatzikyriakidou A, Georgiou I, Tsatsoulis A

Abstract excerpt

BACKGROUND: Age at menarche has a strong genetic influence. We reported recently an association between the XbaI (351A-->C)and PvuII (397T-->C) polymorphisms of the estrogen receptor (ER)alpha gene with the age of menarche in Greek adolescents. In the present study, we examined whether ERbeta genotypes alone, or in combination with ERalpha genotypes, may also influence onset of menarche. METHODS: We performed...

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PMID: 16210384
DOI: 10.1093/humrep/dei326

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