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Article

Lessons from familial myeloproliferative disorders.

Seminars in hematology - 1 Oct 2005

Skoda Radek, Prchal Josef T

Abstract excerpt

By definition, myeloproliferative disorders (MPDs) are caused by an acquired somatic mutation of a hematopoietic progenitor/stem cell and have sporadic occurrence. However, well-documented families exist with first-degree relatives acquiring one or several MPDs. It is reasonable to assume that the germ-line mutation(s) or genetic background must facilitate or predispose for one or several somatic mutation(s) that...

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PMID: 16210040
DOI: 10.1053/j.seminhematol.2005.08.002

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MPL

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