Article
Variability of Clostridium difficile surface proteins and specific serum antibody response in patients with Clostridium difficile-associated disease.
Journal of clinical microbiology - 1 Oct 2005
Péchiné Séverine, Janoir Claire, Collignon Anne
Abstract excerpt
Pathogen attachment is a crucial early step in mucosal infections. This step is mediated by important virulence factors, such as surface proteins. Clostridium difficile surface proteins have been identified as (i) adhesins (the flagellar cap protein FliD; the flagellin FliC; and the cell wall protein Cwp 66 with a two domain-structure [Cw 66 N-terminal and Cwp 66 C-terminal domains]) and (ii) protease (the Cwp 84...
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