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Immunophenotypic modulation in pediatric B lymphoblastic leukemia and its implications in MRD detection

12 Apr 2020

Abstract excerpt

Minimal/Measurable residual disease (MRD) is the most reliable and powerful indicator of prognosis in B cell precursor acute lymphoblastic leukemia (BCP-ALL). Modulation of antigenic expression in leukemic cells is known to occur postchemotherapy and thus carries a potential risk of false MRD quantification by flowcytometry. We studied the immunophenotypic modulation of nine antigens in residual leukemic cells at...

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PMID: 32281503
DOI: 10.1080/10428194.2020.1742902

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