Article
Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue.
Cancer research - 15 Sept 2005
Karenko Leena, Hahtola Sonja, Päivinen Suvi, Karhu Ritva, Syrjä Sanna, Kähkönen Marketta, Nedoszytko Boguslaw, Kytölä Soili, Zhou Ying, Blazevic Vesna, Pesonen Maria, Nevala Hanna, Nupponen Nina, Sihto Harri, Krebs Inge, Poustka Annemarie, Roszkiewicz Jadwiga, Saksela Kalle, Peterson Pärt, Visakorpi Tapio, Ranki Annamari
Abstract excerpt
Multicolor fluorescent in situ hybridization (FISH) was used to identify acquired chromosomal aberrations in 12 patients with mycosis fungoides or Sézary syndrome, the most common forms of primary cutaneous T-cell lymphoma (CTCL). The most frequently affected chromosome was 12, which showed clonal deletions or translocations with a break point in 12q21 or 12q22 in five of seven consecutive Sézary syndrome...
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