Article
Th2 cytokine genotypes are associated with a milder form of primary Sjogren's syndrome.
Annals of the rheumatic diseases - 1 May 2006
Pertovaara M, Antonen J, Hurme M
Abstract excerpt
BACKGROUND: Immunohistological studies on salivary and lacrimal glands have yielded conflicting results on the Th1/Th2 balance in primary Sjögren's syndrome (pSS). OBJECTIVE: To establish whether pSS is a Th1 or Th2 directed autoimmune disease by analysing the polymorphism of the genes encoding for cytokines involved in the regulation of Th1/Th2 differentiation. METHODS: The polymorphisms of the genes encoding...
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