Energy landscape of k-point mutants of an RNA molecule.

Abstract excerpt

MOTIVATION: A k-point mutant of a given RNA sequence s = s(1), ..., s(n) is an RNA sequence s' = s'(1),..., s'(n) obtained by mutating exactly k-positions in s; i.e. Hamming distance between s and s' equals k. To understand the effect of pointwise mutation in RNA, we consider the distribution of energies of all secondary structures of k-point mutants of a given RNA sequence. RESULTS: Here we describe a novel...

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