Denaturing high-performance liquid chromatography screening of the long QT syndrome-related cardiac sodium and potassium channel genes and identification of novel mutations and single nucleotide polymorphisms.

doi:10.1007/s10038-005-0283-3

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Article

Denaturing high-performance liquid chromatography screening of the long QT syndrome-related cardiac sodium and potassium channel genes and identification of novel mutations and single nucleotide polymorphisms.

Journal of human genetics - 1 Jan 2005

Lai Ling-Ping, Su Yi-Ning, Chiang Fu-Tien, Juang Jyh-Ming, Liu Yen-Bin, Ho Yi-Lwun, Chen Wen-Jone, Yeh San-Jou, Wang Chun-Chieh, Ko Yu-Lin, Wu Tsu-Juey, Ueng Kwo-Chang, Lei Meng-Huan, Tsao Hsuan-Ming, Chen Shih-Ann, Lin Tin-Kwang, Wu Mei-Hwan, Lo Huey-Ming, Huang Shoei K Stephen, Lin Jiunn-Lee

Abstract excerpt

Mutations in cardiac potassium and sodium channel genes are responsible for several hereditary cardiac arrhythmia syndromes. We established a denaturing high-performance liquid chromatography (DHPLC) protocol for rapid mutation screening of these genes, and reported mutations and variations identified by this method. We included 28 patients with Brugada syndrome, 4 with congenital long QT syndrome (LQTS), 11 with...

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Identifiers

PMID: 16155735
DOI: 10.1007/s10038-005-0283-3

Genes

KCNH2
KCNQ1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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