Article
Individual and joint association of alpha1A-adrenergic receptor Arg347Cys polymorphism and plasma irbesartan concentration with blood pressure therapeutic response in Chinese hypertensive subjects.
Clinical pharmacology and therapeutics - 1 Sept 2005
Jiang Shanqun, Mao Guangyun, Zhang Shanchun, Hong Xiumei, Tang Genfu, Li Zhiping, Liu Xue, Zhang Yan, Wang Binyan, Xu Xiping, Wang Xiaobin
Abstract excerpt
BACKGROUND: Individual variability in the therapeutic response to an antihypertensive drug could have a genetic basis. We investigated whether the alpha1A-adrenergic receptor (alpha1A-AR) Arg347Cys polymorphism is associated with the blood pressure (BP) therapeutic response to irbesartan and whether the association could be altered by the plasma irbesartan level. METHODS: A total of 696 hypertensive subjects were...
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