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Article

Functional relevance of ceruloplasmin mutations in Parkinson's disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2005

Hochstrasser Helmine, Tomiuk Jürgen, Walter Uwe, Behnke Stefanie, Spiegel Jörg, Krüger Rejko, Becker Georg, Riess Olaf, Berg Daniela

Abstract excerpt

Increased iron levels of the substantia nigra and the discovery of ceruloplasmin mutations in patients with Parkinson's disease (PD) imply impaired iron metabolism in this neurodegenerative disorder. Ceruloplasmin has ferroxidase activity oxidizing iron(II) to iron(III). In the present study, we analyzed the amount of ceruloplasmin, iron, ferritin, and transferrin and the ceruloplasmin ferroxidase activity in...

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PMID: 16150804
DOI: 10.1096/fj.04-3486fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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