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Article

FAS promoter polymorphisms correlate with activity grade in hepatitis C patients.

European journal of gastroenterology & hepatology - 1 Oct 2005

McIlroy Dorian, Théodorou Ioannis, Ratziu Vlad, Vidaud Dominique, Pellet Philippe, Debré Patrice, Poynard Thierry

Abstract excerpt

OBJECTIVE: Hepatocytes are susceptible to FAS-mediated apoptosis. The impact of polymorphisms in the FAS gene on histopathological features of HCV infection was therefore investigated. DESIGN/METHODS: Three single-nucleotide polymorphisms in the FAS promoter were assessed in 190 patients with chronic hepatitis C. Associations between FAS haplotypes and fibrosis stage and activity grade were tested by univariate...

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Topics

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Share to Apoptosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Haplotypes

Share to Hepatitis C, Chronic

Share to Polymerase Chain Reaction

Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 16148554
DOI: 10.1097/00042737-200510000-00012

Genes

FAS
GCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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