Article
Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.
Veterinary pathology - 1 Sept 2005
Dickerson E B, Thomas R, Fosmire S P, Lamerato-Kozicki A R, Bianco S R, Wojcieszyn J W, Breen M, Helfand S C, Modiano J F
Abstract excerpt
We examined the presence of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) abnormalities that could contribute to the origin or progression of naturally occurring canine endothelial tumors (hemangiosarcoma). Our results document somatic point mutations or deletions encompassing the PTEN C-terminal domain in canine hemangiosarcoma that might provide cells a survival advantage within their...
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