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Article

Kinetic, spectroscopic, and X-ray crystallographic characterization of the functional E151H aminopeptidase from Aeromonas proteolytica.

Biochemistry - 13 Sept 2005

Bzymek Krzysztof P, Moulin Aaron, Swierczek Sabina I, Ringe Dagmar, Petsko Gregory A, Bennett Brian, Holz Richard C

Abstract excerpt

Glutamate151 (E151) has been shown to be catalytically essential for the aminopeptidase from Vibrio proteolyticus (AAP). E151 acts as the general acid/base during the catalytic mechanism of peptide hydrolysis. However, a glutamate residue is not the only residue capable of functioning as a general acid/base during catalysis for dinuclear metallohydrolases. Recent crystallographic characterization of the...

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PMID: 16142900
DOI: 10.1021/bi0505823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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