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Article

Association of the mu-opioid receptor gene with type 2 diabetes mellitus in an African American population.

Molecular genetics and metabolism - 1 Jan 2006

Gallagher Carla J, Gordon Candace J, Langefeld Carl D, Mychaleckyj Josyf C, Freedman Barry I, Rich Stephen S, Bowden Donald W, Sale Michèle M

Abstract excerpt

African Americans (AA) are at increased risk for developing type 2 diabetes mellitus (T2DM) relative to European Americans. We previously detected linkage of T2DM to 6q24-q27 (LOD 2.26) at 163.5 cM, closest to marker D6S1035, in a genome-wide scan of AA families. The mu-opioid receptor gene (OPRM1) is located within the LOD-1 support interval of this linkage peak. OPRM1 is an attractive positional candidate gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Share to Kidney Failure, Chronic

Share to Polymorphism, Single Nucleotide

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 16140553
DOI: 10.1016/j.ymgme.2005.07.013

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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