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Article

Intervertebral disc degeneration in relation to the COL9A3 and the IL-1ss gene polymorphisms.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society - 1 May 2006

Solovieva Svetlana, Lohiniva Jaana, Leino-Arjas Päivi, Raininko Raili, Luoma Katariina, Ala-Kokko Leena, Riihimäki Hilkka

Abstract excerpt

Disc degeneration is a complex condition in which environmental factors and multiple genes are expected to act together to determine the degenerative phenotype. Recently associations of COL9A2 (Trp2 allele) and COL9A3 (Trp3 allele) polymorphisms with lumbar disc disease characterized by sciatica have been reported. However, it is not known whether the Trp2 or Trp3 alleles contribute to disc degeneration (DD). In...

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Identifiers

PMID: 16133074
DOI: 10.1007/s00586-005-0988-1
PMCID: PMC3489335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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