The estimation of heritability for twin data based on concordances of sex and disease.

Abstract excerpt

Heritability is an important measure in chronic disease epidemiology. Almost all developed methods of heritability estimation for dichotomous outcomes in twin data are based on concordance of monozygous (MZ) and dizygous (DZ) twins. However, most existing twin registries, which provide a unique and efficient opportunity to assess the putative genetic basis of diseases, do not have zygosity information. We...

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