Article
Response of non-small cell lung cancer cells to the inhibitors of phosphatidylinositol 3-kinase/Akt- and MAPK kinase 4/c-Jun NH2-terminal kinase pathways: an effective therapeutic strategy for lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2005
Lee Ho-Young, Oh Seung-Hyun, Suh Young-Ah, Baek Jin Hyen, Papadimitrakopoulou Vali, Huang Suyun, Hong Waun Ki
Abstract excerpt
PURPOSE: We previously showed that phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK) pathways cooperate to promote non-small cell lung cancer (NSCLC) cell proliferation in vitro. This study was designed to explore whether inhibition of these pathways effectively inhibits NSCLC tumor growth in vivo. EXPERIMENTAL DESIGN: The effects of PI3K/Akt inhibitors {LY294002, adenoviruses...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.