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Article

[Growth inhibition of combined pathway inhibitors on KRAS mutated non-small cell lung cancer cell line].

Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 May 2013

Li Zhan-wen, Yang Zhen-li, Feng Hai-liang, Bian Xiao-cui, Liu Yan-yan, Liu Yu-qin

Abstract excerpt

OBJECTIVE: To investigate the effect of the selective PI3K inhibitor and MEK inhibitor on KRAS and PTEN co-mutated non-small cell lung cancer cell line NCI-H157 and the relevant mechanisms. METHODS: NCI-H157 was cultured routinely and treated with different concentrations of the two inhibitors. Cell proliferation was detected by MTT cell cycle assay. Based on the MTT results the cells were divided into four...

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Identifiers

PMID: 24004591
DOI: 10.3760/cma.j.issn.0529-5807.2013.05.009

Genes

KRAS
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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