Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reverse genetics screen identifies six proteins important for malaria development in the mosquito.

Molecular microbiology - 1 Oct 2008

Ecker Andrea, Bushell Ellen S C, Tewari Rita, Sinden Robert E

Abstract excerpt

Transmission from the vertebrate host to the mosquito vector represents a major population bottleneck in the malaria life cycle that can successfully be targeted by intervention strategies. However, to date only about 25 parasite proteins expressed during this critical phase have been functionally analysed by gene disruption. We describe the first systematic, larger scale generation and phenotypic analysis of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Culicidae
Share to Gene Targeting
Share to Genes, Protozoan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Malaria

Share to Plasmodium berghei

Share to Proteomics

Share to Protozoan Proteins

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 18761621
DOI: 10.1111/j.1365-2958.2008.06407.x
PMCID: PMC2658712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reverse genetics screen identifies six proteins important for malaria development in the mosquito.PMID 18761621Read ↗

Characterization of P lasmodium developmental transcriptomes in A nopheles gambiae midgut reveals novel regulators of malaria transmissionSemantic proximity Read ↗

A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasiteSemantic proximity Read ↗

Phylogenetic profiles of all membrane transport proteins of the malaria parasite highlight new drug targetsSemantic proximity Read ↗

Identification of Three Novel Plasmodium Factors Involved in Ookinete to Oocyst Developmental TransitionSemantic proximity Read ↗

A Novel Tool for the Generation of Conditional Knockouts To Study Gene Function across the Plasmodium falciparum Life CycleSemantic proximity Read ↗

Plasmodium berghei PIMMS2 Promotes Ookinete Invasion of the Anopheles gambiae Mosquito MidgutSemantic proximity Read ↗

From the genome to the phenome: tools to understand the basic biology of Plasmodium falciparum.Semantic proximity Read ↗

Identification of genes required for Plasmodium gametocyte-to-sporozoite development in the mosquito vectorSemantic proximity Read ↗

Identification of three ookinete-specific genes and evaluation of their transmission-blocking potentials in Plasmodium bergheiSemantic proximity Read ↗

Effects of mosquito genes on Plasmodium development.Semantic proximity Read ↗

Sexual Development in Plasmodium: Lessons from Functional AnalysesSemantic proximity Read ↗

Reverse genetic screen identifies malaria parasite genes required for gametocyte-to-sporozoite development in its mosquito hostSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.