Article
Iron acquisition from transferrin by Candida albicans depends on the reductive pathway.
Infection and immunity - 1 Sept 2005
Knight Simon A B, Vilaire Gaston, Lesuisse Emmanuel, Dancis Andrew
Abstract excerpt
Host-pathogen interactions that alter virulence are influenced by critical nutrients such as iron. In humans, free iron is unavailable, being present only in high-affinity iron binding proteins such as transferrin. The fungal pathogen Candida albicans grows as a saprophyte on mucosal surfaces. Occasionally it invades systemically, and in this circumstance it will encounter transferrin iron. Here we report that C....
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