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Article

Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism.

Stem cells (Dayton, Ohio) - 1 Jan 2006

Fu Yu-Show, Cheng Yun-Chih, Lin Maan-Yuh Anya, Cheng Henrich, Chu Pei-Ming, Chou Shih-Chich, Shih Yang-Hsin, Ko Miau-Hwa, Sung Min-Shan

Abstract excerpt

Human mesenchymal stem cells isolated from Wharton's jelly of the umbilical cord were induced to transform into dopaminergic neurons in vitro through stepwise culturing in neuron-conditioned medium, sonic hedgehog, and FGF8. The success rate was 12.7%, as characterized by positive staining for tyrosine hydroxylase (TH), the rate-limiting catecholaminergic synthesizing enzyme, and dopamine being released into the...

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Source

Identifiers

PMID: 16099997
DOI: 10.1634/stemcells.2005-0053

Genes

FGF8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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