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Article

A common pathway for genetic events leading to pheochromocytoma.

Cancer cell - 1 Aug 2005

Maxwell Patrick H

Abstract excerpt

Mutations in VHL, RET, NF1, SDHB, SDHC, and SDHD can give rise to pheochromocytoma/paraganglioma. These different genetic lesions may all act by decreasing the activity of a 2-oxoglutarate-dependent oxygenase, SM-20/EglN3/PHD3, resulting in reduced apoptosis of neural crest cells during development.

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Topics

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Share to Adrenal Gland Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

Share to Hypoxia-Inducible Factor-Proline Dioxygenases

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Source

Identifiers

PMID: 16098460
DOI: 10.1016/j.ccr.2005.07.012

Genes

RET
SDHB
SDHC
SDHD
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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