Article
Cytokinetic failure and asynchronous nuclear division in BHK cells overexpressing a truncated protein-tyrosine-phosphatase.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1992
Cool D E, Andreassen P R, Tonks N K, Krebs E G, Fischer E H, Margolis R L
Abstract excerpt
Previous work has shown that a T-cell protein-tyrosine-phosphatase truncated in its carboxyl-terminal domain (delta C11.PTP) has full enzymatic activity but no longer localizes in the particulate fraction of the cell. Two baby hamster kidney (BHK) cell lines overexpressing the truncated protein are markedly multinucleate, a state likely caused by a failure in cytokinesis. Nuclei within syncytial cells...
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