Article
Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene.
Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2005
Timmer John R, Mak Tracy W, Manova Katia, Anderson Kathryn V, Niswander Lee
Abstract excerpt
Adhesive properties of cells undergoing morphogenetic rearrangements can be regulated either at the cellular level or by altering the environment in which rearrangements occur. Here, we describe the identification of a mutation (my(F11)) in the mouse extracellular matrix component Frem2, and provide evidence that suggests Frem2 expression creates an environment conducive to morphogenetic events. Loss of Frem2...
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