Article
Genetic reprogramming of tumor cells by zinc finger transcription factors.
Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2005
Blancafort Pilar, Chen Emily I, Gonzalez Beatriz, Bergquist Sharon, Zijlstra Andries, Guthy Daniel, Brachat Arndt, Brakenhoff Ruud H, Quigley James P, Erdmann Dirk, Barbas Carlos F
Abstract excerpt
Cancer arises by the accumulation of genetic alterations in DNA leading to aberrant gene transcription. Expression-profiling studies have correlated genomewide expression signatures with malignancy. However, functional analysis elucidating the contribution and synergy of genes in specific cancer cell phenotypes remains a formidable obstacle. Herein, we describe an alternative genetic approach for identification...
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