Article
NF-Ya activates multiple hematopoietic stem cell (HSC) regulatory genes and promotes HSC self-renewal.
Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2005
Zhu Jiang, Zhang Yi, Joe Gerard J, Pompetti Richard, Emerson Stephen G
Abstract excerpt
Hematopoietic stem cell (HSC) self-renewal and differentiation are influenced through multiple pathways, including homeobox transcription factors, signaling through beta-catenin and Notch-1, telomerase, and p27. How these multiple pathways interact and are orchestrated is currently unknown. We now report that NF-Ya, the regulatory and DNA-binding subunit of the trimeric transcription factor NF-Y, plays a central,...
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